6NHA

Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody

6NHA の概要

• エントリーDOI: 10.2210/pdb6nha/pdb
• 分子名称: IgG receptor FcRn large subunit p51, Beta-2-microglobulin, SYNT001-Fab light chain, ... (6 entities in total)
• 機能のキーワード: fcrn, b2m, circulating igg and igg immune complex, synt001, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 90404.19

構造登録者

Blumberg, R.S.,Cheung, J.,Mahmood, A.,Gandhi, A.K. (登録日: 2018-12-21, 公開日: 2019-12-25, 最終更新日: 2023-10-11)

• 主引用文献: Blumberg, L.J.,Humphries, J.E.,Jones, S.D.,Pearce, L.B.,Holgate, R.,Hearn, A.,Cheung, J.,Mahmood, A.,Del Tito, B.,Graydon, J.S.,Stolz, L.E.,Bitonti, A.,Purohit, S.,de Graaf, D.,Kacena, K.,Andersen, J.T.,Christianson, G.J.,Roopenian, D.C.,Hubbard, J.J.,Gandhi, A.K.,Lasseter, K.,Pyzik, M.,Blumberg, R.S.; Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.; Sci Adv, 5:eaax9586-eaax9586, 2019; PubMed: 31897428; DOI: 10.1126/sciadv.aax9586

実験手法

X-RAY DIFFRACTION (2.381 Å)