Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein

Summary for 6NBH

EMDB information0411
DescriptorParathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ... (8 entities in total)
Functional Keywordsparathyroid hormone receptor, gpcr, class b gpcr, gpcr-g protein complex, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight165860.57
Primary citation
Zhao, L.H.,Ma, S.,Sutkeviciute, I.,Shen, D.D.,Zhou, X.E.,de Waal, P.W.,Li, C.Y.,Kang, Y.,Clark, L.J.,Jean-Alphonse, F.G.,White, A.D.,Yang, D.,Dai, A.,Cai, X.,Chen, J.,Li, C.,Jiang, Y.,Watanabe, T.,Gardella, T.J.,Melcher, K.,Wang, M.W.,Vilardaga, J.P.,Xu, H.E.,Zhang, Y.
Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364:148-153, 2019
PubMed: 30975883 (PDB entries with the same primary citation)
DOI: 10.1126/science.aav7942
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers200MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

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Molmil generated image of 6nbh
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