6NBH
Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0001917 | cellular_component | photoreceptor inner segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| B | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0010659 | biological_process | cardiac muscle cell apoptotic process |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0030425 | cellular_component | dendrite |
| B | 0030507 | molecular_function | spectrin binding |
| B | 0042622 | cellular_component | photoreceptor outer segment membrane |
| B | 0044297 | cellular_component | cell body |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0047391 | molecular_function | alkylglycerophosphoethanolamine phosphodiesterase activity |
| B | 0050909 | biological_process | sensory perception of taste |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0071456 | biological_process | cellular response to hypoxia |
| G | 0003924 | molecular_function | GTPase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005834 | cellular_component | heterotrimeric G-protein complex |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0007165 | biological_process | signal transduction |
| G | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| G | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| G | 0016020 | cellular_component | membrane |
| G | 0031681 | molecular_function | G-protein beta-subunit binding |
| G | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| G | 0071870 | biological_process | cellular response to catecholamine stimulus |
| P | 0005179 | molecular_function | hormone activity |
| P | 0005576 | cellular_component | extracellular region |
| P | 0030282 | biological_process | bone mineralization |
| R | 0004888 | molecular_function | transmembrane signaling receptor activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004991 | molecular_function | parathyroid hormone receptor activity |
| R | 0007166 | biological_process | cell surface receptor signaling pathway |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue CLR R 601 |
| Chain | Residue |
| R | TRP322 |
| R | VAL326 |
| R | CLR607 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CLR R 602 |
| Chain | Residue |
| R | ILE422 |
| R | ALA426 |
| R | PRO428 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CLR R 603 |
| Chain | Residue |
| R | TRP361 |
| R | PRO428 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CLR R 604 |
| Chain | Residue |
| R | VAL382 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CLR R 605 |
| Chain | Residue |
| R | ALA279 |
| R | THR286 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CLR R 606 |
| Chain | Residue |
| R | ASN358 |
| R | LYS359 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CLR R 607 |
| Chain | Residue |
| R | PHE291 |
| R | CLR601 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue PLM R 608 |
| Chain | Residue |
| R | ALA275 |
| R | TYR278 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. ClpeWDhil.CWplGapgevvavpCP |
| Chain | Residue | Details |
| R | CYS108-PRO132 |
| site_id | PS00650 |
| Number of Residues | 16 |
| Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFFVaIIYCFcNgeV |
| Chain | Residue | Details |
| R | GLN451-VAL466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641 |
| Chain | Residue | Details |
| A | GLY47 | |
| A | ASP223 | |
| A | ASN292 | |
| A | ALA366 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10427002, ECO:0000269|PubMed:11087399, ECO:0000269|PubMed:15591060, ECO:0000269|PubMed:19243146, ECO:0000269|PubMed:9395396, ECO:0000269|PubMed:9417641, ECO:0000305|PubMed:16766715 |
| Chain | Residue | Details |
| A | SER54 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63092 |
| Chain | Residue | Details |
| R | HIS307-TYR320 | |
| R | ARG383-SER409 | |
| A | SER352 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P63092 |
| Chain | Residue | Details |
| A | LYS300 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P10824 |
| Chain | Residue | Details |
| A | LEU198 | |
| A | THR204 | |
| A | ASP173 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | LIPID: N-myristoyl glycine => ECO:0000250|UniProtKB:P63096 |
| Chain | Residue | Details |
| A | GLY2 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824 |
| Chain | Residue | Details |
| A | CYS3 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| R | THR410-PRO428 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| R | MET441-ASN463 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN151 | |
| R | ASN161 | |
| R | ASN166 | |
| R | ASN176 |
