6N5C

Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PCF2Am-InsP5

6N5C の概要

• エントリーDOI: 10.2210/pdb6n5c/pdb
• 分子名称: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: inositol, inositol polyphosphate, inositol pyrophosphate, analog, phosphonodifluoroacetamide, diphosphoinositol pentakisphosphate, kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39396.85

構造登録者

Wang, H.,Shears, S.B.,Riley, A.,Potter, B. (登録日: 2018-11-21, 公開日: 2019-08-21, 最終更新日: 2023-10-11)

• 主引用文献: Riley, A.M.,Wang, H.,Shears, S.B.,Potter, B.V.L.; Synthesis of an alpha-phosphono-alpha , alpha-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7.; Medchemcomm, 10:1165-1172, 2019; PubMed: 31391889; DOI: 10.1039/c9md00163h

実験手法

X-RAY DIFFRACTION (1.95 Å)