6N46
Crystal structure of the cryptic polo box domain of a human activated Plk4
Summary for 6N46
Entry DOI | 10.2210/pdb6n46/pdb |
Descriptor | Serine/threonine-protein kinase PLK4 (1 entity in total) |
Functional Keywords | polo-like kinase 4, protein phosphorylation, centriole duplication, pcm organization, phase separation, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 230542.03 |
Authors | Park, J.-E.,DiMaio, F.,Zhang, L.,Lee, K.S. (deposition date: 2018-11-17, release date: 2019-09-04, Last modification date: 2023-10-11) |
Primary citation | Park, J.E.,Zhang, L.,Bang, J.K.,Andresson, T.,DiMaio, F.,Lee, K.S. Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat Commun, 10:4959-4959, 2019 Cited by PubMed: 31672968DOI: 10.1038/s41467-019-12619-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.708 Å) |
Structure validation
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