6N0Z

Crystal structure of Anaerolinea thermophila mevalonate 5-phosphate decarboxylase N20K H194M mutant complexed with (R)-MVAPP

Summary for 6N0Z

DescriptorDiphosphomevalonate decarboxylase, (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID (3 entities in total)
Functional Keywordslyase
Biological sourceAnaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)
Total number of polymer chains6
Total molecular weight216365.32
Authors
Noel, J.P.,Thomas, S.T.,Louie, G.V. (deposition date: 2018-11-07, release date: 2019-07-17)
Primary citation
Thomas, S.T.,Louie, G.V.,Lubin, J.W.,Lundblad, V.,Noel, J.P.
Substrate specificity and engineering of mevalonate 5-phosphate decarboxylase.
Acs Chem.Biol., 2019
PubMed: 31268677 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.9b00322
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2027 0.2% 1.3% 4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution