6N0Z
Crystal structure of Anaerolinea thermophila mevalonate 5-phosphate decarboxylase N20K H194M mutant complexed with (R)-MVAPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| C | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| D | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| E | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0008299 | biological_process | isoprenoid biosynthetic process |
| E | 0016831 | molecular_function | carboxy-lyase activity |
| E | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| F | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0008299 | biological_process | isoprenoid biosynthetic process |
| F | 0016831 | molecular_function | carboxy-lyase activity |
| F | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue DP6 A 401 |
| Chain | Residue |
| A | ALA13 |
| A | SER140 |
| A | ARG143 |
| A | SER190 |
| A | THR191 |
| A | MET194 |
| A | ASP280 |
| A | HOH518 |
| A | HOH557 |
| A | HOH571 |
| A | HOH632 |
| A | LYS16 |
| A | TYR17 |
| A | LYS20 |
| A | ARG26 |
| A | ARG71 |
| A | SER106 |
| A | SER138 |
| A | GLY139 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue DP6 B 401 |
| Chain | Residue |
| B | ALA13 |
| B | TYR17 |
| B | LYS20 |
| B | ARG26 |
| B | ARG71 |
| B | SER106 |
| B | SER138 |
| B | GLY139 |
| B | SER140 |
| B | ARG143 |
| B | SER190 |
| B | THR191 |
| B | MET194 |
| B | ASP280 |
| B | HOH536 |
| B | HOH548 |
| B | HOH566 |
| B | HOH631 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue DP6 C 401 |
| Chain | Residue |
| C | ALA13 |
| C | TYR17 |
| C | LYS20 |
| C | ARG26 |
| C | ARG71 |
| C | SER138 |
| C | GLY139 |
| C | SER140 |
| C | ARG143 |
| C | SER190 |
| C | THR191 |
| C | MET194 |
| C | ASP280 |
| C | HOH557 |
| C | HOH561 |
| C | HOH564 |
| C | HOH567 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue DP6 D 401 |
| Chain | Residue |
| D | ALA13 |
| D | LYS16 |
| D | TYR17 |
| D | LYS20 |
| D | ARG26 |
| D | ARG71 |
| D | SER106 |
| D | SER138 |
| D | GLY139 |
| D | SER140 |
| D | ARG143 |
| D | SER190 |
| D | THR191 |
| D | MET194 |
| D | ASP280 |
| D | HOH551 |
| D | HOH559 |
| D | HOH595 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue DP6 E 401 |
| Chain | Residue |
| E | ALA13 |
| E | TYR17 |
| E | LYS20 |
| E | ARG26 |
| E | ARG71 |
| E | SER106 |
| E | SER138 |
| E | GLY139 |
| E | SER140 |
| E | ARG143 |
| E | SER190 |
| E | THR191 |
| E | MET194 |
| E | ASP280 |
| E | HOH528 |
| E | HOH543 |
| E | HOH571 |
| E | HOH592 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | binding site for residue DP6 F 401 |
| Chain | Residue |
| F | ARG143 |
| F | SER190 |
| F | THR191 |
| F | MET194 |
| F | ASP280 |
| F | HOH542 |
| F | HOH550 |
| F | HOH580 |
| F | HOH624 |
| F | ALA13 |
| F | TYR17 |
| F | LYS20 |
| F | ARG26 |
| F | ARG71 |
| F | SER106 |
| F | SER138 |
| F | GLY139 |
| F | SER140 |
