6MZQ

TAS-120 in reversible binding mode with FGFR1

Summary for 6MZQ

Entry DOI	10.2210/pdb6mzq/pdb
Descriptor	Fibroblast growth factor receptor 1, 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one (3 entities in total)
Functional Keywords	fgfr1, tas-120, inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	71544.12
Authors	Kalyukina, M.,Squire, C.J. (deposition date: 2018-11-05, release date: 2019-01-16, Last modification date: 2023-10-11)
Primary citation	Kalyukina, M.,Yosaatmadja, Y.,Middleditch, M.J.,Patterson, A.V.,Smaill, J.B.,Squire, C.J. TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure. ChemMedChem, 14:494-500, 2019 Cited by PubMed: 30600916 DOI: 10.1002/cmdc.201800719 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation