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6MZQ

TAS-120 in reversible binding mode with FGFR1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005007molecular_functionfibroblast growth factor receptor activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005007molecular_functionfibroblast growth factor receptor activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue TZ0 A 801
ChainResidue
ALEU484
AASN568
AARG627
ALEU630
AALA640
AASP641
APHE642
AHOH910
AALA512
ALYS514
AGLU531
AMET535
AILE545
AGLU562
ATYR563
AALA564

site_idAC2
Number of Residues11
Detailsbinding site for residue TZ0 B 801
ChainResidue
BLEU484
BALA512
BLYS514
BGLU531
BGLU562
BTYR563
BALA564
BLEU630
BALA640
BASP641
BPHE642

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues31
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK
ChainResidueDetails
ALEU484-LYS514

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV
ChainResidueDetails
ACYS619-VAL631

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AASP468-ALA488
BASP468-ALA488

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897
ChainResidueDetails
ALYS714
BLYS714

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING:
ChainResidueDetails
AALA575
BASN659
BARG718
BMET732
ATYR605
ATYR653
AASN659
AARG718
AMET732
BALA575
BTYR605
BTYR653

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Breakpoint for translocation to form FGFR1OP2-FGFR1 => ECO:0000269|PubMed:15034873, ECO:0000269|PubMed:16946300, ECO:0000269|PubMed:17389761
ChainResidueDetails
AASP519
BASP519

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
ChainResidueDetails
AASP554
AASP674
AILE676
BASP554
BASP674
BILE676

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:8622701
ChainResidueDetails
AARG744
APRO745
BARG744
BPRO745

226707

PDB entries from 2024-10-30

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