6MWJ

Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) Burkholderia pseudomallei in complex with ligand HGN-0863

Summary for 6MWJ

• Entry DOI: 10.2210/pdb6mwj/pdb
• Descriptor: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ... (5 entities in total)
• Functional Keywords: ssgcid, structural genomics, seattle structural genomics center for infectious disease, lyase
• Biological source: Burkholderia pseudomallei (strain 1710b)
• Total number of polymer chains: 3
• Total formula weight: 53140.51

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2018-10-29, release date: 2019-11-06, Last modification date: 2025-04-09)

• Primary citation: Grote, D.,Stewart, C.G.,Daraji, D.G.,Enayati, P.,Braverman, K.N.,Romanaggi, C.,Bolejack, M.J.,Yano, J.K.,Abendroth, J.,Dranow, D.M.,Pierce, P.G.,Lorimer, D.D.,Horanyi, P.S.,Staker, B.L.,Edwards, T.E.,Myler, P.J.,Horn, J.R.,Hagen, T.J.; Analysis of Burkholderia pseudomallei IspF in complex with sulfapyridine, sulfamonomethoxine, ethoxzolamide and acetazolamide; Acta Crystallogr.,Sect.F, 81:138-145, 2025

Experimental method

X-RAY DIFFRACTION (2.05 Å)