6MSO

Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate

Summary for 6MSO

Entry DOI	10.2210/pdb6mso/pdb
Descriptor	fumarate hydratase, IRON/SULFUR CLUSTER, GLYCEROL, ... (6 entities in total)
Functional Keywords	inhibitor, mitochondrial, fumarate hydratase, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Leishmania major
Total number of polymer chains	4
Total formula weight	263979.52
Authors	Feliciano, P.R.,Drennan, C.L.,Nonato, M.C. (deposition date: 2018-10-17, release date: 2019-01-30, Last modification date: 2023-10-11)
Primary citation	Feliciano, P.R.,Drennan, C.L.,Nonato, M.C. Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate. ACS Chem. Biol., 14:266-275, 2019 Cited by PubMed: 30645090 DOI: 10.1021/acschembio.8b00972 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.053 Å)

Structure validation