6MNX

Structural basis of impaired hydrolysis in KRAS Q61H mutant

Summary for 6MNX

• Entry DOI: 10.2210/pdb6mnx/pdb
• Descriptor: GTPase KRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: gtpase kras hydrolysis, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 118975.57

Authors

Bera, A.K.,Westover, K.D. (deposition date: 2018-10-03, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Zhou, Z.W.,Ambrogio, C.,Bera, A.K.,Li, Q.,Li, X.X.,Li, L.,Son, J.,Gondi, S.,Li, J.,Campbell, E.,Jin, H.,Okoro, J.J.,Xu, C.X.,Janne, P.A.,Westover, K.D.; KRASQ61HPreferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer.; Cancer Res., 80:3719-3731, 2020; PubMed: 32605999; DOI: 10.1158/0008-5472.CAN-20-0448

Experimental method

X-RAY DIFFRACTION (2.2 Å)