6MNH

ULK1 Unc-51 like autophagy activating kinase in complex with inhibitor BTC

Summary for 6MNH

Entry DOI	10.2210/pdb6mnh/pdb
Descriptor	Serine/threonine-protein kinase ULK1, N-[(2R)-3-methylbutan-2-yl]-1H-benzotriazole-6-carboxamide, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	kinase, inhibitor, complex, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32937.99
Authors	Hendle, J.,Sauder, J.M.,Hickey, M.J.,Rauch, C.T.,Maletic, M.,Schwinn, K.D. (deposition date: 2018-10-01, release date: 2019-03-27, Last modification date: 2019-11-13)
Primary citation	Nicolaou, C.A.,Humblet, C.,Hu, H.,Martin, E.M.,Dorsey, F.C.,Castle, T.M.,Burton, K.I.,Hu, H.,Hendle, J.,Hickey, M.J.,Duerksen, J.,Wang, J.,Erickson, J.A. Idea2Data: Toward a New Paradigm for Drug Discovery. Acs Med.Chem.Lett., 10:278-286, 2019 Cited by PubMed: 30891127 DOI: 10.1021/acsmedchemlett.8b00488 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation