6MN4

Crystal structure of aminoglycoside acetyltransferase AAC(3)-IVa, H154A mutant, in complex with apramycin

6MN4 の概要

• エントリーDOI: 10.2210/pdb6mn4/pdb
• 分子名称: Aminoglycoside N(3)-acetyltransferase, AAC(3)-IVa, APRAMYCIN, ZINC ION, ... (8 entities in total)
• 機能のキーワード: antibiotic_nat family, acetyltransferase, aminoglycoside, antibiotic resistance, coenzyme a, apramycin, aac(3)-iva, csgid, transferase, center for structural genomics of infectious diseases, national institute of allergy and infectious diseases, niaid, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 174397.77

構造登録者

Stogios, P.J.,Evdokimova, E.,Michalska, K.,Di Leo, R.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2018-10-01, 公開日: 2018-10-24, 最終更新日: 2023-10-11)

• 主引用文献: Stogios, P.J.,Bordeleau, E.,Xu, Z.,Skarina, T.,Evdokimova, E.,Chou, S.,Diorio-Toth, L.,D'Souza, A.W.,Patel, S.,Dantas, G.,Wright, G.D.,Savchenko, A.; Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.; Commun Biol, 5:263-263, 2022; PubMed: 35338238; DOI: 10.1038/s42003-022-03219-w

実験手法

X-RAY DIFFRACTION (2.8 Å)