6MJZ

Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174

Summary for 6MJZ

• Entry DOI: 10.2210/pdb6mjz/pdb
• EMDB information: 9135
• Descriptor: Fusion glycoprotein F0, PIA174 Fab Heavy chain, PIA174 Fab Light chain (3 entities in total)
• Functional Keywords: hpiv3 envelope, asymmetric, complex, antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human parainfluenza virus 3; More
• Total number of polymer chains: 5
• Total formula weight: 211110.57

Authors

Acharya, P.,Stewart-Jones, G.,Carragher, B.,Potter, C.S.,Kwong, P.D. (deposition date: 2018-09-24, release date: 2018-11-14, Last modification date: 2019-12-18)

• Primary citation: Stewart-Jones, G.B.E.,Chuang, G.Y.,Xu, K.,Zhou, T.,Acharya, P.,Tsybovsky, Y.,Ou, L.,Zhang, B.,Fernandez-Rodriguez, B.,Gilardi, V.,Silacci-Fregni, C.,Beltramello, M.,Baxa, U.,Druz, A.,Kong, W.P.,Thomas, P.V.,Yang, Y.,Foulds, K.E.,Todd, J.P.,Wei, H.,Salazar, A.M.,Scorpio, D.G.,Carragher, B.,Potter, C.S.,Corti, D.,Mascola, J.R.,Lanzavecchia, A.,Kwong, P.D.; Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.; Proc. Natl. Acad. Sci. U.S.A., 115:12265-12270, 2018; PubMed: 30420505; DOI: 10.1073/pnas.1811980115

Experimental method

ELECTRON MICROSCOPY (4.3 Å)