6MID

Cryo-EM structure of the ZIKV virion in complex with Fab fragments of the potently neutralizing human monoclonal antibody ZIKV-195

Summary for 6MID

• Entry DOI: 10.2210/pdb6mid/pdb
• EMDB information: 9131
• Descriptor: E protein, M protein, monoclonal antibody ZIKV-195 heavy chain, ... (5 entities in total)
• Functional Keywords: virus, monoclonal antibody, complex, virus-immune system complex, virus/immune system
• Biological source: Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV); More
• Total number of polymer chains: 8
• Total formula weight: 215995.65

Authors

Long, F.,Rossmann, M.G. (deposition date: 2018-09-19, release date: 2019-01-16, Last modification date: 2020-07-29)

• Primary citation: Long, F.,Doyle, M.,Fernandez, E.,Miller, A.S.,Klose, T.,Sevvana, M.,Bryan, A.,Davidson, E.,Doranz, B.J.,Kuhn, R.J.,Diamond, M.S.,Crowe Jr., J.E.,Rossmann, M.G.; Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope.; Proc. Natl. Acad. Sci. U.S.A., 116:1591-1596, 2019; PubMed: 30642974; DOI: 10.1073/pnas.1815432116

Experimental method

ELECTRON MICROSCOPY (4 Å)