6MHG

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

Summary for 6MHG

• Entry DOI: 10.2210/pdb6mhg/pdb
• EMDB information: 9114
• Descriptor: circumsporozoite protein, Fab311 heavy chain, Fab311 light chain (3 entities in total)
• Functional Keywords: plasmodium falciparum, antibody, csp, rscsp, immune system
• Biological source: Plasmodium falciparum; More
• Total number of polymer chains: 23
• Total formula weight: 548105.13

Authors

Cottrell, C.A.,Torres, J.L.,Ward, A.B. (deposition date: 2018-09-17, release date: 2018-10-31)

• Primary citation: Oyen, D.,Torres, J.L.,Cottrell, C.A.,Richter King, C.,Wilson, I.A.,Ward, A.B.; Cryo-EM structure ofP. falciparumcircumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.; Sci Adv, 4:eaau8529-eaau8529, 2018; PubMed: 30324137; DOI: 10.1126/sciadv.aau8529

Experimental method

ELECTRON MICROSCOPY (3.57 Å)