6MEH

Crystal structure of broadly neutralizing antibody HEPC74 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

Summary for 6MEH

Entry DOI	10.2210/pdb6meh/pdb
Descriptor	E2 glycoprotein, antibody HEPC74 Heavy Chain, antibody HEPC74 Light Chain, ... (6 entities in total)
Functional Keywords	hcv glycoprotein, broadly neutralizing antibodies, immune system
Biological source	Hepacivirus C More
Total number of polymer chains	3
Total formula weight	79314.48
Authors	Flyak, A.I.,Bjorkman, P.J. (deposition date: 2018-09-06, release date: 2018-11-21, Last modification date: 2023-10-11)
Primary citation	Flyak, A.I.,Ruiz, S.,Colbert, M.D.,Luong, T.,Crowe Jr., J.E.,Bailey, J.R.,Bjorkman, P.J. HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. Cell Host Microbe, 24:703-716.e3, 2018 Cited by PubMed: 30439340 DOI: 10.1016/j.chom.2018.10.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation