6MEE

Crystal structure of broadly neutralizing antibody HEPC74

Summary for 6MEE

Entry DOI	10.2210/pdb6mee/pdb
Descriptor	antibody HEPC74 Heavy Chain, antibody HEPC74 Light Chain (3 entities in total)
Functional Keywords	hcv glycoprotein, broadly neutralizing antibodies, immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	97711.14
Authors	Flyak, A.I.,Bjorkman, P.J. (deposition date: 2018-09-06, release date: 2018-11-21, Last modification date: 2023-10-11)
Primary citation	Flyak, A.I.,Ruiz, S.,Colbert, M.D.,Luong, T.,Crowe Jr., J.E.,Bailey, J.R.,Bjorkman, P.J. HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design. Cell Host Microbe, 24:703-716.e3, 2018 Cited by PubMed: 30439340 DOI: 10.1016/j.chom.2018.10.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation