Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946

Summary for 6MAM

DescriptorADI-15946 Fab Heavy Chain, ADI-15946 Fab Light Chain, Envelope glycoprotein, ... (7 entities in total)
Functional Keywordsebola, ebolavirus, antibody, mab, fab, gp, glycoprotein, cleaved, monoclonal, broad, filovirus, marburg, ebov, bdbv, sudv, restv, tafv, marv, ravv, bundibugyo, sudan, human, viral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains12
Total molecular weight264670.68
West, B.R.,Moyer, C.L.,Fusco, M.L.,Saphire, E.O. (deposition date: 2018-08-28, release date: 2019-03-20, Last modification date: 2019-04-10)
Primary citation
West, B.R.,Wec, A.Z.,Moyer, C.L.,Fusco, M.L.,Ilinykh, P.A.,Huang, K.,Wirchnianski, A.S.,James, R.M.,Herbert, A.S.,Hui, S.,Goodwin, E.,Howell, K.A.,Kailasan, S.,Aman, M.J.,Walker, L.M.,Dye, J.M.,Bukreyev, A.,Chandran, K.,Saphire, E.O.
Structural basis of broad ebolavirus neutralization by a human survivor antibody.
Nat. Struct. Mol. Biol., 26:204-212, 2019
PubMed: 30833785 (PDB entries with the same primary citation)
DOI: 10.1038/s41594-019-0191-4
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers 0.283700MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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