6MAC

Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD

6MAC の概要

• エントリーDOI: 10.2210/pdb6mac/pdb
• 分子名称: Growth/differentiation factor 11, Activin receptor type-2B, TGF-beta receptor type-1, ... (5 entities in total)
• 機能のキーワード: growth factor, receptor, tgfb, signaling, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 32901.17

構造登録者

Goebel, E.J.,Thompson, T.B. (登録日: 2018-08-27, 公開日: 2019-07-17, 最終更新日: 2023-10-11)

• 主引用文献: Goebel, E.J.,Corpina, R.A.,Hinck, C.S.,Czepnik, M.,Castonguay, R.,Grenha, R.,Boisvert, A.,Miklossy, G.,Fullerton, P.T.,Matzuk, M.M.,Idone, V.J.,Economides, A.N.,Kumar, R.,Hinck, A.P.,Thompson, T.B.; Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.; Proc.Natl.Acad.Sci.USA, 116:15505-15513, 2019; PubMed: 31315975; DOI: 10.1073/pnas.1906253116

実験手法

X-RAY DIFFRACTION (2.34 Å)