6M2N

SARS-CoV-2 3CL protease (3CL pro) in complex with a novel inhibitor

Summary for 6M2N

Entry DOI	10.2210/pdb6m2n/pdb
Descriptor	3C-like proteinase, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one (3 entities in total)
Functional Keywords	sars-cov-2, 3cl pro, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains	4
Total formula weight	136383.14
Authors	Su, H.X.,Zhao, W.F.,Li, M.J.,Xie, H.,Xu, Y.C. (deposition date: 2020-02-28, release date: 2020-04-15, Last modification date: 2023-11-29)
Primary citation	Su, H.X.,Yao, S.,Zhao, W.F.,Li, M.J.,Liu, J.,Shang, W.J.,Xie, H.,Ke, C.Q.,Hu, H.C.,Gao, M.N.,Yu, K.Q.,Liu, H.,Shen, J.S.,Tang, W.,Zhang, L.K.,Xiao, G.F.,Ni, L.,Wang, D.W.,Zuo, J.P.,Jiang, H.L.,Bai, F.,Wu, Y.,Ye, Y.,Xu, Y.C. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacol.Sin., 41:1167-1177, 2020 Cited by PubMed: 32737471 DOI: 10.1038/s41401-020-0483-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.198 Å)

Structure validation