Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6M2N

SARS-CoV-2 3CL protease (3CL pro) in complex with a novel inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0008233molecular_functionpeptidase activity
A0019082biological_processviral protein processing
B0008233molecular_functionpeptidase activity
B0019082biological_processviral protein processing
C0008233molecular_functionpeptidase activity
C0019082biological_processviral protein processing
D0008233molecular_functionpeptidase activity
D0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 3WL A 401
ChainResidue
AHIS41
AASP187
AHOH532
ACYS44
AMET49
ALEU141
AASN142
AGLY143
ACYS145
AMET165
AGLU166

site_idAC2
Number of Residues11
Detailsbinding site for residue 3WL B 401
ChainResidue
BHIS41
BLEU141
BASN142
BGLY143
BSER144
BCYS145
BMET165
BGLU166
BASP187
BGLN189
BHOH545

site_idAC3
Number of Residues10
Detailsbinding site for residue 3WL C 401
ChainResidue
CHIS41
CMET49
CLEU141
CASN142
CGLY143
CSER144
CCYS145
CMET165
CGLU166
CHOH525

site_idAC4
Number of Residues7
Detailsbinding site for residue 3WL D 401
ChainResidue
DHIS41
DLEU141
DASN142
DGLY143
DCYS145
DMET165
DGLU166

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291
ChainResidueDetails
AHIS41
BHIS41
CHIS41
DHIS41

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291
ChainResidueDetails
ACYS145
BCYS145
CCYS145
DCYS145

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
AGLN306
BGLN306
CGLN306
DGLN306

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon