6M2B
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416
Summary for 6M2B
Entry DOI | 10.2210/pdb6m2b/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, biosynthetic protein, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43620.69 |
Authors | |
Primary citation | Xiong, R.,Zhang, L.,Li, S.,Sun, Y.,Ding, M.,Wang, Y.,Zhao, Y.,Wu, Y.,Shang, W.,Jiang, X.,Shan, J.,Shen, Z.,Tong, Y.,Xu, L.,Chen, Y.,Liu, Y.,Zou, G.,Lavillete, D.,Zhao, Z.,Wang, R.,Zhu, L.,Xiao, G.,Lan, K.,Li, H.,Xu, K. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell, 11:723-739, 2020 Cited by PubMed: 32754890DOI: 10.1007/s13238-020-00768-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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