6LXY

IRAK4 in complex with inhibitor

Summary for 6LXY

• Entry DOI: 10.2210/pdb6lxy/pdb
• Descriptor: Interleukin-1 receptor-associated kinase 4, N-[(2R)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: irak4, kinase, inhibitor, cancer, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 138792.35

Authors

Ghosh, K.,Bose, S. (deposition date: 2020-02-12, release date: 2020-11-25)

• Primary citation: Nair, S.,Kumar, S.R.,Paidi, V.R.,Sistla, R.,Kantheti, D.,Polimera, S.R.,Thangavel, S.,Mukherjee, A.J.,Das, M.,Bhide, R.S.,Pitts, W.J.,Murugesan, N.,Dudhgoankar, S.,Nagar, J.,Subramani, S.,Mazumder, D.,Carman, J.A.,Holloway, D.A.,Li, X.,Fereshteh, M.P.,Ruepp, S.,Palanisamy, K.,Mariappan, T.T.,Maddi, S.,Saxena, A.,Elzinga, P.,Chimalakonda, A.,Ruan, Q.,Ghosh, K.,Bose, S.,Sack, J.,Yan, C.,Kiefer, S.E.,Xie, D.,Newitt, J.A.,Saravanakumar, S.P.,Rampulla, R.A.,Barrish, J.C.,Carter, P.H.,Hynes Jr., J.; Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.; Acs Med.Chem.Lett., 11:1402-1409, 2020; PubMed: 32676146; DOI: 10.1021/acsmedchemlett.0c00082

Experimental method

X-RAY DIFFRACTION (2.19 Å)