6LXY
IRAK4 in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D, E | Interleukin-1 receptor-associated kinase 4 | polymer | 305 | 34192.6 | 4 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | A, B, D, E | N-[(2R)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide | non-polymer | 433.5 | 4 | Chemie (EXF) | |||
| 3 | B, D, E | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 160 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 156 | - | expression tag |
| Ala 157 | - | expression tag |
| Met 158 | - | expression tag |
| Gly 159 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 136770.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2022.0 | |
| All* | Total formula weight | 138792.4 |
