6LW1
Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form
Summary for 6LW1
Entry DOI | 10.2210/pdb6lw1/pdb |
EMDB information | 30002 |
Descriptor | Toll-like receptor 7, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine (2 entities in total) |
Functional Keywords | tlr7, antagonist, immune system |
Biological source | Macaca mulatta (Rhesus macaque) |
Total number of polymer chains | 2 |
Total formula weight | 190466.33 |
Authors | |
Primary citation | Tojo, S.,Zhang, Z.,Matsui, H.,Tahara, M.,Ikeguchi, M.,Kochi, M.,Kamada, M.,Shigematsu, H.,Tsutsumi, A.,Adachi, N.,Shibata, T.,Yamamoto, M.,Kikkawa, M.,Senda, T.,Isobe, Y.,Ohto, U.,Shimizu, T. Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11:5204-5204, 2020 Cited by PubMed: 33060576DOI: 10.1038/s41467-020-19025-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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