6LVK

Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative

Summary for 6LVK

• Entry DOI: 10.2210/pdb6lvk/pdb
• Descriptor: Fibroblast growth factor receptor 2, N-ethyl-2-[[4-[[4-(4-methylpiperazin-1-yl)-3-(2-morpholin-4-ylethoxy)phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: protein kinase, signaling protein, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 73352.15

Authors

Echizen, Y.,Amano, Y.,Tateishi, Y. (deposition date: 2020-02-04, release date: 2020-04-08, Last modification date: 2023-11-29)

• Primary citation: Kuriwaki, I.,Kameda, M.,Hisamichi, H.,Kikuchi, S.,Iikubo, K.,Kawamoto, Y.,Moritomo, H.,Kondoh, Y.,Amano, Y.,Tateishi, Y.,Echizen, Y.,Iwai, Y.,Noda, A.,Tomiyama, H.,Suzuki, T.,Hirano, M.; Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.; Bioorg.Med.Chem., 28:115453-115453, 2020; PubMed: 32278710; DOI: 10.1016/j.bmc.2020.115453

Experimental method

X-RAY DIFFRACTION (2.29 Å)