6LVK

Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative

6LVK の概要

• エントリーDOI: 10.2210/pdb6lvk/pdb
• 分子名称: Fibroblast growth factor receptor 2, N-ethyl-2-[[4-[[4-(4-methylpiperazin-1-yl)-3-(2-morpholin-4-ylethoxy)phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: protein kinase, signaling protein, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73352.15

構造登録者

Echizen, Y.,Amano, Y.,Tateishi, Y. (登録日: 2020-02-04, 公開日: 2020-04-08, 最終更新日: 2023-11-29)

• 主引用文献: Kuriwaki, I.,Kameda, M.,Hisamichi, H.,Kikuchi, S.,Iikubo, K.,Kawamoto, Y.,Moritomo, H.,Kondoh, Y.,Amano, Y.,Tateishi, Y.,Echizen, Y.,Iwai, Y.,Noda, A.,Tomiyama, H.,Suzuki, T.,Hirano, M.; Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.; Bioorg.Med.Chem., 28:115453-115453, 2020; PubMed: 32278710; DOI: 10.1016/j.bmc.2020.115453

実験手法

X-RAY DIFFRACTION (2.29 Å)