6LJK
Crystal structure of human Sirt5 in complex with an internally quenched fluorescent substrate GluIQF
Summary for 6LJK
Entry DOI | 10.2210/pdb6ljk/pdb |
Descriptor | NAD-dependent protein deacylase sirtuin-5, mitochondrial, BE2-SER-ALA-ILE-LYS-SER-NIY-GLY-SET, ZINC ION, ... (6 entities in total) |
Functional Keywords | sirt5, inhibitor, hydrolase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 30765.21 |
Authors | |
Primary citation | Yang, L.L.,Wang, H.L.,Yan, Y.H.,Liu, S.,Yu, Z.J.,Huang, M.Y.,Luo, Y.,Zheng, X.,Yu, Y.,Li, G.B. Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur.J.Med.Chem., 192:112201-112201, 2020 Cited by PubMed: 32163813DOI: 10.1016/j.ejmech.2020.112201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.394 Å) |
Structure validation
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