6LIN

Crystal structure of human PDK2 complexed with GM10030

Summary for 6LIN

• Entry DOI: 10.2210/pdb6lin/pdb
• Related: 6LIL
• Descriptor: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, SULFATE ION, GLYCEROL, ... (6 entities in total)
• Functional Keywords: mitochondria, kinase, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 188144.74

Authors

Kang, J.,Kim, J. (deposition date: 2019-12-12, release date: 2020-09-30, Last modification date: 2023-11-22)

• Primary citation: Kang, J.,Pagire, H.S.,Kang, D.,Song, Y.H.,Lee, I.K.,Lee, K.T.,Park, C.J.,Ahn, J.H.,Kim, J.; Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds.; Biochem.Biophys.Res.Commun., 527:778-784, 2020; PubMed: 32444142; DOI: 10.1016/j.bbrc.2020.04.102

Experimental method

X-RAY DIFFRACTION (2.67 Å)