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6LIN

Crystal structure of human PDK2 complexed with GM10030

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0005967cellular_componentobsolete mitochondrial pyruvate dehydrogenase complex
A0006006biological_processglucose metabolic process
A0006111biological_processregulation of gluconeogenesis
A0006885biological_processregulation of pH
A0008286biological_processinsulin receptor signaling pathway
A0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
A0010565biological_processregulation of cellular ketone metabolic process
A0010906biological_processregulation of glucose metabolic process
A0016301molecular_functionkinase activity
A0031670biological_processcellular response to nutrient
A0034614biological_processcellular response to reactive oxygen species
A0042593biological_processglucose homeostasis
A0042803molecular_functionprotein homodimerization activity
A0045254cellular_componentpyruvate dehydrogenase complex
A0050848biological_processregulation of calcium-mediated signaling
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0004672molecular_functionprotein kinase activity
B0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0005967cellular_componentobsolete mitochondrial pyruvate dehydrogenase complex
B0006006biological_processglucose metabolic process
B0006111biological_processregulation of gluconeogenesis
B0006885biological_processregulation of pH
B0008286biological_processinsulin receptor signaling pathway
B0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
B0010565biological_processregulation of cellular ketone metabolic process
B0010906biological_processregulation of glucose metabolic process
B0016301molecular_functionkinase activity
B0031670biological_processcellular response to nutrient
B0034614biological_processcellular response to reactive oxygen species
B0042593biological_processglucose homeostasis
B0042803molecular_functionprotein homodimerization activity
B0045254cellular_componentpyruvate dehydrogenase complex
B0050848biological_processregulation of calcium-mediated signaling
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
C0004672molecular_functionprotein kinase activity
C0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005654cellular_componentnucleoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0005967cellular_componentobsolete mitochondrial pyruvate dehydrogenase complex
C0006006biological_processglucose metabolic process
C0006111biological_processregulation of gluconeogenesis
C0006885biological_processregulation of pH
C0008286biological_processinsulin receptor signaling pathway
C0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
C0010565biological_processregulation of cellular ketone metabolic process
C0010906biological_processregulation of glucose metabolic process
C0016301molecular_functionkinase activity
C0031670biological_processcellular response to nutrient
C0034614biological_processcellular response to reactive oxygen species
C0042593biological_processglucose homeostasis
C0042803molecular_functionprotein homodimerization activity
C0045254cellular_componentpyruvate dehydrogenase complex
C0050848biological_processregulation of calcium-mediated signaling
C0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
D0004672molecular_functionprotein kinase activity
D0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005654cellular_componentnucleoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0005967cellular_componentobsolete mitochondrial pyruvate dehydrogenase complex
D0006006biological_processglucose metabolic process
D0006111biological_processregulation of gluconeogenesis
D0006885biological_processregulation of pH
D0008286biological_processinsulin receptor signaling pathway
D0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
D0010565biological_processregulation of cellular ketone metabolic process
D0010906biological_processregulation of glucose metabolic process
D0016301molecular_functionkinase activity
D0031670biological_processcellular response to nutrient
D0034614biological_processcellular response to reactive oxygen species
D0042593biological_processglucose homeostasis
D0042803molecular_functionprotein homodimerization activity
D0045254cellular_componentpyruvate dehydrogenase complex
D0050848biological_processregulation of calcium-mediated signaling
D0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue SO4 A 401
ChainResidue
AARG298
ALYS299
AARG302

site_idAC2
Number of Residues2
Detailsbinding site for residue GOL A 402
ChainResidue
AARG166
AASN170

site_idAC3
Number of Residues18
Detailsbinding site for residue EH0 A 403
ChainResidue
AASP290
AGLY292
AGLY294
AVAL295
ALYS299
ALEU303
ATYR308
AGLY327
ALEU330
ALEU346
AGLU350
ATHR354
AHOH503
AHOH511
ALEU252
AASN255
AARG258
AALA259

site_idAC4
Number of Residues4
Detailsbinding site for residue SO4 B 401
ChainResidue
BARG166
BASN170
BHIS247
BTYR336

site_idAC5
Number of Residues17
Detailsbinding site for residue EH0 B 402
ChainResidue
BLEU252
BASN255
BALA256
BARG258
BALA259
BASP290
BGLY294
BVAL295
BLYS299
BLEU303
BGLY327
BGLY329
BLEU330
BLEU346
BTHR354
BHOH508
BHOH509

site_idAC6
Number of Residues5
Detailsbinding site for residue PEG C 401
ChainResidue
CARG162
CARG166
CASN170
CHIS247
CTYR336

site_idAC7
Number of Residues18
Detailsbinding site for residue EH0 C 402
ChainResidue
CLEU252
CASN255
CARG258
CALA259
CASP290
CGLY292
CGLY294
CVAL295
CPRO296
CLYS299
CLEU303
CSER309
CLEU330
CLEU346
CTHR354
CHOH502
CHOH504
CHOH511

site_idAC8
Number of Residues18
Detailsbinding site for residue EH0 D 401
ChainResidue
DLEU252
DASN255
DALA256
DARG258
DALA259
DASP290
DGLY294
DVAL295
DLYS299
DLEU303
DGLY327
DLEU330
DLEU346
DGLU350
DTHR354
DHOH501
DHOH504
DHOH518

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:16401071
ChainResidueDetails
AGLU251
DGLU251
DASP290
DGLY325
AASP290
AGLY325
BGLU251
BASP290
BGLY325
CGLU251
CASP290
CGLY325

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ASER309
BSER309
CSER309
DSER309

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q15118
ChainResidueDetails
ATYR215
ATYR216
BTYR215
BTYR216
CTYR215
CTYR216
DTYR215
DTYR216

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BFP9
ChainResidueDetails
ALYS376
BLYS376
CLYS376
DLYS376

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PDB entries from 2024-07-24

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