Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6LIN

Crystal structure of human PDK2 complexed with GM10030

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006111	biological_process	regulation of gluconeogenesis
A	0006885	biological_process	regulation of pH
A	0008286	biological_process	insulin receptor signaling pathway
A	0010510	biological_process	regulation of pyruvate decarboxylation to acetyl-CoA
A	0010565	biological_process	regulation of ketone metabolic process
A	0010906	biological_process	regulation of glucose metabolic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0031670	biological_process	cellular response to nutrient
A	0033554	biological_process	cellular response to stress
A	0034614	biological_process	cellular response to reactive oxygen species
A	0042593	biological_process	glucose homeostasis
A	0042803	molecular_function	protein homodimerization activity
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006111	biological_process	regulation of gluconeogenesis
B	0006885	biological_process	regulation of pH
B	0008286	biological_process	insulin receptor signaling pathway
B	0010510	biological_process	regulation of pyruvate decarboxylation to acetyl-CoA
B	0010565	biological_process	regulation of ketone metabolic process
B	0010906	biological_process	regulation of glucose metabolic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0031670	biological_process	cellular response to nutrient
B	0033554	biological_process	cellular response to stress
B	0034614	biological_process	cellular response to reactive oxygen species
B	0042593	biological_process	glucose homeostasis
B	0042803	molecular_function	protein homodimerization activity
B	0045254	cellular_component	pyruvate dehydrogenase complex
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
C	0000166	molecular_function	nucleotide binding
C	0004672	molecular_function	protein kinase activity
C	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005654	cellular_component	nucleoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006111	biological_process	regulation of gluconeogenesis
C	0006885	biological_process	regulation of pH
C	0008286	biological_process	insulin receptor signaling pathway
C	0010510	biological_process	regulation of pyruvate decarboxylation to acetyl-CoA
C	0010565	biological_process	regulation of ketone metabolic process
C	0010906	biological_process	regulation of glucose metabolic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0031670	biological_process	cellular response to nutrient
C	0033554	biological_process	cellular response to stress
C	0034614	biological_process	cellular response to reactive oxygen species
C	0042593	biological_process	glucose homeostasis
C	0042803	molecular_function	protein homodimerization activity
C	0045254	cellular_component	pyruvate dehydrogenase complex
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
D	0000166	molecular_function	nucleotide binding
D	0004672	molecular_function	protein kinase activity
D	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005654	cellular_component	nucleoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006111	biological_process	regulation of gluconeogenesis
D	0006885	biological_process	regulation of pH
D	0008286	biological_process	insulin receptor signaling pathway
D	0010510	biological_process	regulation of pyruvate decarboxylation to acetyl-CoA
D	0010565	biological_process	regulation of ketone metabolic process
D	0010906	biological_process	regulation of glucose metabolic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0031670	biological_process	cellular response to nutrient
D	0033554	biological_process	cellular response to stress
D	0034614	biological_process	cellular response to reactive oxygen species
D	0042593	biological_process	glucose homeostasis
D	0042803	molecular_function	protein homodimerization activity
D	0045254	cellular_component	pyruvate dehydrogenase complex
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 401

Chain	Residue
A	ARG298
A	LYS299
A	ARG302

site_id	AC2
Number of Residues	2
Details	binding site for residue GOL A 402

Chain	Residue
A	ARG166
A	ASN170

site_id	AC3
Number of Residues	18
Details	binding site for residue EH0 A 403

Chain	Residue
A	ASP290
A	GLY292
A	GLY294
A	VAL295
A	LYS299
A	LEU303
A	TYR308
A	GLY327
A	LEU330
A	LEU346
A	GLU350
A	THR354
A	HOH503
A	HOH511
A	LEU252
A	ASN255
A	ARG258
A	ALA259

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 401

Chain	Residue
B	ARG166
B	ASN170
B	HIS247
B	TYR336

site_id	AC5
Number of Residues	17
Details	binding site for residue EH0 B 402

Chain	Residue
B	LEU252
B	ASN255
B	ALA256
B	ARG258
B	ALA259
B	ASP290
B	GLY294
B	VAL295
B	LYS299
B	LEU303
B	GLY327
B	GLY329
B	LEU330
B	LEU346
B	THR354
B	HOH508
B	HOH509

site_id	AC6
Number of Residues	5
Details	binding site for residue PEG C 401

Chain	Residue
C	ARG162
C	ARG166
C	ASN170
C	HIS247
C	TYR336

site_id	AC7
Number of Residues	18
Details	binding site for residue EH0 C 402

Chain	Residue
C	LEU252
C	ASN255
C	ARG258
C	ALA259
C	ASP290
C	GLY292
C	GLY294
C	VAL295
C	PRO296
C	LYS299
C	LEU303
C	SER309
C	LEU330
C	LEU346
C	THR354
C	HOH502
C	HOH504
C	HOH511

site_id	AC8
Number of Residues	18
Details	binding site for residue EH0 D 401

Chain	Residue
D	LEU252
D	ASN255
D	ALA256
D	ARG258
D	ALA259
D	ASP290
D	GLY294
D	VAL295
D	LYS299
D	LEU303
D	GLY327
D	LEU330
D	LEU346
D	GLU350
D	THR354
D	HOH501
D	HOH504
D	HOH518

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16401071","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q15118","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BFP9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)