6LG8

crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-2138

Summary for 6LG8

• Entry DOI: 10.2210/pdb6lg8/pdb
• Descriptor: Bromodomain-containing protein 4, 2-azanyl-5-fluoranyl-4-imidazol-1-yl-quinolin-8-ol (3 entities in total)
• Functional Keywords: brd4, inhibitor, complex, dna binding protein, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15127.41

Authors

Xu, H.,Zuo, Y.,Zhang, H. (deposition date: 2019-12-04, release date: 2020-12-09, Last modification date: 2023-11-22)

• Primary citation: Xu, H.,Zuo, Y.,Zhang, H.,Luo, C.; Lead-Opt: An efficient tool for structural optimization of lead compounds; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.58 Å)