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6LG8

crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-2138

Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue ECR A 201
ChainResidue
APRO82
AVAL87
ALEU92
AASP96
ATYR139
AASN140
AILE146
AHOH337

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

226707

PDB entries from 2024-10-30

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