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6LEG

Structure of E. coli beta-glucuronidase complex with uronic isofagomine

Summary for 6LEG
Entry DOI10.2210/pdb6leg/pdb
DescriptorBeta-D-glucuronidase, (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid (3 entities in total)
Functional Keywordsinhibitor, isofagomine, glycosidase, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains4
Total formula weight275284.12
Authors
Lin, H.-Y.,Kuo, Y.-H.,Lin, C.-H. (deposition date: 2019-11-25, release date: 2021-01-27, Last modification date: 2023-11-22)
Primary citationLin, H.Y.,Chen, C.Y.,Lin, T.C.,Yeh, L.F.,Hsieh, W.C.,Gao, S.,Burnouf, P.A.,Chen, B.M.,Hsieh, T.J.,Dashnyam, P.,Kuo, Y.H.,Tu, Z.,Roffler, S.R.,Lin, C.H.
Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity.
Commun Biol, 4:280-280, 2021
Cited by
PubMed: 33664385
DOI: 10.1038/s42003-021-01815-w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.603 Å)
Structure validation

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