6LDC

Structure of Bifidobacterium dentium beta-glucuronidase complexed with C6-nonyl uronic isofagomine

Summary for 6LDC

• Entry DOI: 10.2210/pdb6ldc/pdb
• Descriptor: LacZ1 Beta-galactosidase, (2~{S},3~{S},4~{R},5~{R})-2-nonyl-4,5-bis(oxidanyl)piperidine-3-carboxylic acid (3 entities in total)
• Functional Keywords: inhibitor, glycosidase, isofagomine, hydrolase
• Biological source: Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 / Bd1)
• Total number of polymer chains: 4
• Total formula weight: 299504.17

Authors

Lin, H.-Y.,Hsieh, T.-J.,Lin, C.-H. (deposition date: 2019-11-20, release date: 2021-01-27, Last modification date: 2023-11-22)

• Primary citation: Lin, H.Y.,Chen, C.Y.,Lin, T.C.,Yeh, L.F.,Hsieh, W.C.,Gao, S.,Burnouf, P.A.,Chen, B.M.,Hsieh, T.J.,Dashnyam, P.,Kuo, Y.H.,Tu, Z.,Roffler, S.R.,Lin, C.H.; Entropy-driven binding of gut bacterial beta-glucuronidase inhibitors ameliorates irinotecan-induced toxicity.; Commun Biol, 4:280-280, 2021; PubMed: 33664385; DOI: 10.1038/s42003-021-01815-w

Experimental method

X-RAY DIFFRACTION (2.181 Å)