6L89
Human PPARgamma ligand binding domain complexed with Butyrolactone 1
Summary for 6L89
| Entry DOI | 10.2210/pdb6l89/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, methyl (2R)-3-(4-hydroxyphenyl)-2-[[3-(3-methylbut-2-enyl)-4-oxidanyl-phenyl]methyl]-4-oxidanyl-5-oxidanylidene-furan-2-carboxylate (3 entities in total) |
| Functional Keywords | nuclear receptor ligand binding domain butyrolactone 1 partial agonist, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 66236.53 |
| Authors | Jang, D.M.,Han, B.W. (deposition date: 2019-11-05, release date: 2020-09-16, Last modification date: 2023-11-22) |
| Primary citation | Ahn, S.,Jang, D.M.,Park, S.C.,An, S.,Shin, J.,Han, B.W.,Noh, M. Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor gamma. Biomolecules, 10:-, 2020 Cited by PubMed: 32054125DOI: 10.3390/biom10020275 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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