6L84

Complex of DNA polymerase IV and D-DNA duplex

Summary for 6L84

• Entry DOI: 10.2210/pdb6l84/pdb
• Descriptor: DNA polymerase IV, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*CP*C)-3'), DNA (5'-D(P*CP*GP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ... (5 entities in total)
• Functional Keywords: dpo4, d-dna duplex, dna polymerase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2); More
• Total number of polymer chains: 3
• Total formula weight: 51207.59

Authors

Chung, H.S.,An, J.,Hwang, D. (deposition date: 2019-11-04, release date: 2020-07-08, Last modification date: 2023-11-22)

Primary citation

An, J.,Choi, J.,Hwang, D.,Park, J.,Pemble 4th, C.W.,Duong, T.H.M.,Kim, K.R.,Ahn, H.,Chung, H.S.,Ahn, D.R.
The crystal structure of a natural DNA polymerase complexed with mirror DNA.
Chem.Commun.(Camb.), 56:2186-2189, 2020

PubMed Abstract: The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.

PubMed: 31971182
DOI: 10.1039/c9cc09351f

Experimental method

X-RAY DIFFRACTION (2.602 Å)