6L7L
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide
Summary for 6L7L
Entry DOI | 10.2210/pdb6l7l/pdb |
Descriptor | Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 154936.97 |
Authors | Miyahara, S.,Chong, K.T.,Suzuki, T. (deposition date: 2019-11-01, release date: 2020-11-04, Last modification date: 2023-11-22) |
Primary citation | Miyahara, S.,Hara, S.,Chong, K.T.,Suzuki, T.,Ogino, Y.,Hoshino, T.,Tsukioka, S.,Yano, W.,Suzuki, M.,Otsu, Y.,Yonekura, T.,Ito, S.,Terasaka, M.,Suzuki, T.,Hashimoto, A. TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published, |
Experimental method | X-RAY DIFFRACTION (2.171 Å) |
Structure validation
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