6L7L
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, E) | Ribonucleoside-diphosphate reductase large subunit | polymer | 669 | 76189.9 | 2 | UniProt (P23921) Pfam (PF00317) Pfam (PF02867) | Homo sapiens (Human) | Ribonucleotide reductase R1 subunit |
| 2 | C, K (A, E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, L (A, E) | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 2 | Chemie (TTP) | |||
| 4 | E, M (A, E) | 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide | non-polymer | 476.9 | 2 | Chemie (E6O) | |||
| 5 | F, G, H, I, J... (A, E) | ACETATE ION | non-polymer | 59.0 | 10 | Chemie (ACT) | |||
| 6 | S, T (A, E) | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A, E: 75 - 742 (UniProt: P23921)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 152379.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2557.3 | |
| All* | Total formula weight | 154937.0 |
