6L6R
Crystal structure of LRP6 E1E2-SOST complex
Summary for 6L6R
Entry DOI | 10.2210/pdb6l6r/pdb |
Descriptor | Low-density lipoprotein receptor-related protein 6, Sclerostin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | lrp6, sclerostin, wnt signaling, inhibitor, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 179362.10 |
Authors | Choi, H.-J.,Kim, J. (deposition date: 2019-10-29, release date: 2020-10-28, Last modification date: 2023-11-22) |
Primary citation | Kim, J.,Han, W.,Park, T.,Kim, E.J.,Bang, I.,Lee, H.S.,Jeong, Y.,Roh, K.,Kim, J.,Kim, J.S.,Kang, C.,Seok, C.,Han, J.-K.,Choi, H.-J. Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. Nat Commun, 11:5357-5357, 2020 Cited by PubMed: 33097721DOI: 10.1038/s41467-020-19155-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.8 Å) |
Structure validation
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