6KYK

Crystal structure of Shank3 NTD-ANK mutant in complex with Rap1

Summary for 6KYK

• Entry DOI: 10.2210/pdb6kyk/pdb
• Related: 6KYH
• Descriptor: SH3 and multiple ankyrin repeat domains protein 3, Ras-related protein Rap-1b, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
• Functional Keywords: shank3, gtpase, synaptic scaffold protein, structural protein-signaling protein complex, structural protein/signaling protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 162226.76

Authors

Cai, Q.,Zhang, M. (deposition date: 2019-09-19, release date: 2019-12-04, Last modification date: 2023-11-22)

• Primary citation: Cai, Q.,Hosokawa, T.,Zeng, M.,Hayashi, Y.,Zhang, M.; Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.; Structure, 28:290-, 2020; PubMed: 31879129; DOI: 10.1016/j.str.2019.11.018

Experimental method

X-RAY DIFFRACTION (2.82 Å)