6KYH

Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas

Summary for 6KYH

• Entry DOI: 10.2210/pdb6kyh/pdb
• Descriptor: SH3 and multiple ankyrin repeat domains protein 3, GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (4 entities in total)
• Functional Keywords: shank3, gtpase, synaptic scaffold protein, structural protein-signaling protein complex, structural protein/signaling protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 8
• Total formula weight: 240414.66

Authors

Cai, Q.,Zhang, M. (deposition date: 2019-09-18, release date: 2019-12-04, Last modification date: 2023-11-22)

• Primary citation: Cai, Q.,Hosokawa, T.,Zeng, M.,Hayashi, Y.,Zhang, M.; Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.; Structure, 28:290-, 2020; PubMed: 31879129; DOI: 10.1016/j.str.2019.11.018

Experimental method

X-RAY DIFFRACTION (3.3 Å)