6KSF

Crystal Structure of ALKBH1 bound to 21-mer DNA bulge

Summary for 6KSF

• Entry DOI: 10.2210/pdb6ksf/pdb
• Descriptor: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 1, DNA (5'-D(*DGP*DCP*DTP*DGP*DAP*DGP*DTP*DGP*DCP*DCP*DCP*DGP*DCP*DGP*DTP*DGP*DCP*DTP*DGP*DGP*DAP*DTP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DAP*DTP*DCP*DCP*DAP*DGP*DCP*DAP*DCP*DGP*DCP*DCP*DAP*DCP*DTP*DCP*DAP*DGP*DC)-3'), ... (7 entities in total)
• Functional Keywords: dna methylation, complex, demethylase, gene regulation
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 52109.35

Authors

Li, H.,Zhang, M. (deposition date: 2019-08-23, release date: 2020-04-08, Last modification date: 2023-11-22)

• Primary citation: Zhang, M.,Yang, S.,Nelakanti, R.,Zhao, W.,Liu, G.,Li, Z.,Liu, X.,Wu, T.,Xiao, A.,Li, H.; Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA.; Cell Res., 30:197-210, 2020; PubMed: 32051560; DOI: 10.1038/s41422-019-0237-5

Experimental method

X-RAY DIFFRACTION (2.4 Å)