6KHD
Crystal structure of CLK1 in complex with CX-4945
Summary for 6KHD
Entry DOI | 10.2210/pdb6khd/pdb |
Descriptor | Dual specificity protein kinase CLK1, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (3 entities in total) |
Functional Keywords | cdc2-like kinase, casein kinase, cx-4945, alternative splicing, splicing, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 173017.34 |
Authors | Lee, J.Y.,Yun, J.S.,Jin, H.,Chang, J.H. (deposition date: 2019-07-15, release date: 2019-10-02, Last modification date: 2024-03-27) |
Primary citation | Lee, J.Y.,Yun, J.S.,Kim, W.K.,Chun, H.S.,Jin, H.,Cho, S.,Chang, J.H. Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945. Biomed Res Int, 2019:6125068-6125068, 2019 Cited by PubMed: 31531359DOI: 10.1155/2019/6125068 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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