6JO8
The complex structure of CHIKV envelope glycoprotein bound to human MXRA8
Summary for 6JO8
| Entry DOI | 10.2210/pdb6jo8/pdb |
| Descriptor | Togavirin, CHIKV E1, Matrix remodeling-associated protein 8, ... (5 entities in total) |
| Functional Keywords | arthritogenic alphaviruses, receptor, mxra8, chikungunya virus, viral protein |
| Biological source | Chikungunya virus (CHIKV) More |
| Total number of polymer chains | 9 |
| Total formula weight | 367679.12 |
| Authors | |
| Primary citation | Song, H.,Zhao, Z.,Chai, Y.,Jin, X.,Li, C.,Yuan, F.,Liu, S.,Gao, Z.,Wang, H.,Song, J.,Vazquez, L.,Zhang, Y.,Tan, S.,Morel, C.M.,Yan, J.,Shi, Y.,Qi, J.,Gao, F.,Gao, G.F. Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein. Cell, 177:1714-1724.e12, 2019 Cited by PubMed Abstract: Arthritogenic alphaviruses, such as Chikungunya virus (CHIKV), cause severe and debilitating rheumatic diseases worldwide, resulting in severe morbidity and economic costs. Recently, MXRA8 was reported as an entry receptor. Here, we present the crystal structures of the mouse MXRA8, human MXRA8 in complex with the CHIKV E protein, and the cryo-electron microscopy structure of human MXRA8 and CHIKV virus-like particle. MXRA8 has two Ig-like domains with unique structural topologies. This receptor binds in the "canyon" between two protomers of the E spike on the surface of the virion. The atomic details at the interface between the two binding entities reveal that both the two domains and the hinge region of MXRA8 are involved in interaction with CHIKV E1-E2 residues from two protomers. Notably, the stalk region of MXRA8 is critical for CHIKV virus entry. This finding provides important information regarding the development of therapeutic countermeasures against those arthritogenic alphaviruses. PubMed: 31080063DOI: 10.1016/j.cell.2019.04.008 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.495 Å) |
Structure validation
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