6JN2

Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10

Summary for 6JN2

• Entry DOI: 10.2210/pdb6jn2/pdb
• Descriptor: Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific (2 entities in total)
• Functional Keywords: hdot1l, haf10, leucine zipper, heterodimer, tetramerization, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 20577.39

Authors

Song, X.,Wang, M.,Yang, N.,Xu, R.M. (deposition date: 2019-03-13, release date: 2019-09-18, Last modification date: 2024-03-27)

• Primary citation: Song, X.,Yang, L.,Wang, M.,Gu, Y.,Ye, B.,Fan, Z.,Xu, R.M.,Yang, N.; A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.; Proc.Natl.Acad.Sci.USA, 116:19917-19923, 2019; PubMed: 31527241; DOI: 10.1073/pnas.1904672116

Experimental method

X-RAY DIFFRACTION (3.6 Å)