6JN2

Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein AF-10	polymer	98	11161.5	1	UniProt (P55197)	Homo sapiens (Human)	ALL1-fused gene from chromosome 10 protein
2	B (B)	Histone-lysine N-methyltransferase, H3 lysine-79 specific	polymer	82	9415.9	1	UniProt (Q8TEK3)	Homo sapiens (Human)	DOT1-like protein,Histone H3-K79 methyltransferase,H3-K79-HMTase,Lysine N-methyltransferase 4

Sequence modifications

A: 699 - 782 (UniProt: P55197)

PDB	External Database	Details
Met 685	-	expression tag
Gly 686	-	expression tag
Ser 687	-	expression tag
Ser 688	-	expression tag
His 689	-	expression tag
His 690	-	expression tag
His 691	-	expression tag
His 692	-	expression tag
His 693	-	expression tag
His 694	-	expression tag
Ser 695	-	expression tag
Gln 696	-	expression tag
Asp 697	-	expression tag
Pro 698	-	expression tag

B: 470 - 550 (UniProt: Q8TEK3)

PDB	External Database	Details
Met 469	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20577.4
All*	Total formula weight	20577.4

*Water molecules are not included.