6JM9
cryo-EM structure of DOT1L bound to unmodified nucleosome
Summary for 6JM9
Entry DOI | 10.2210/pdb6jm9/pdb |
EMDB information | 9843 9844 |
Descriptor | DNA strand I, DNA strand J, Histone H3.2, ... (8 entities in total) |
Functional Keywords | histone, nucleosome, methylation, gene regulation |
Biological source | synthetic construct More |
Total number of polymer chains | 11 |
Total formula weight | 201592.86 |
Authors | Jang, S.,Song, J.J. (deposition date: 2019-03-07, release date: 2019-05-15, Last modification date: 2024-03-27) |
Primary citation | Jang, S.,Kang, C.,Yang, H.S.,Jung, T.,Hebert, H.,Chung, K.Y.,Kim, S.J.,Hohng, S.,Song, J.J. Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase. Genes Dev., 33:620-625, 2019 Cited by PubMed: 30923167DOI: 10.1101/gad.323790.118 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (7.3 Å) |
Structure validation
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