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6JM9

cryo-EM structure of DOT1L bound to unmodified nucleosome

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1IDNA strand Ipolymer12337890.31synthetic construct
2JDNA strand Jpolymer12338010.31synthetic construct
3A, EHistone H3.2polymer9811488.42UniProt (P84233)
Pfam (PF00125)
In PDB
Xenopus laevis (African clawed frog)
4B, FHistone H4polymer879990.82UniProt (P62799)
Pfam (PF15511)
In PDB
Xenopus laevis (African clawed frog)
5C, GHistone H2Apolymer10711724.72UniProt (Q6AZJ8)
Pfam (PF00125)
Pfam (PF16211)
In PDB
Xenopus laevis (African clawed frog)
6D, HHistone H2B 1.1polymer9410478.02UniProt (P02281)
Pfam (PF00125)
In PDB
Xenopus laevis (African clawed frog)H2B1.1
7XHistone-lysine N-methyltransferase, H3 lysine-79 specificpolymer32837930.01UniProt (Q8TEK3)
Pfam (PF08123)
In PDB
Homo sapiens (Human)DOT1-like protein
8XS-ADENOSYLMETHIONINEnon-polymer398.41Chemie (SAM)
Sequence modifications
D, H: 30 - 122 (UniProt: P02281)
PDBExternal DatabaseDetails
Thr 29-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains11
Total formula weight201194.4
Non-Polymers*Number of molecules1
Total formula weight398.4
All*Total formula weight201592.9
*Water molecules are not included.

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PDB entries from 2024-09-18

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